Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor-Reference-Cited by-同舟云学术

Synthesis of Six-Membered N-Heterocyclic Carbene Precursors Based on Camphor

Published:2023-12-06 Issue:24 Volume:28 Page:7973
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Šegina Jan¹,Ciber Luka¹,Brodnik Helena¹,Požgan Franc¹^ORCID,Svete Jurij¹^ORCID,Štefane Bogdan¹^ORCID,Grošelj Uroš¹^ORCID

Affiliation:

1. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna Pot 113, 1000 Ljubljana, Slovenia

Abstract

The endo- and exo-N-heterocyclic carbene precursors based on camphor were prepared diastereoselectively in five synthetic steps starting from (1S)-(+)-ketopinic acid. The obtained N-heterocyclic carbene precursors were investigated in an asymmetric benzoin reaction. All new compounds were fully characterized, and the absolute configurations were determined via X-ray diffraction and NOESY measurements.

Funder

Slovenian Research Agency

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/28/24/7973/pdf

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