Anti-Inflammatory Properties of the Citrus Flavonoid Diosmetin: An Updated Review of Experimental Models
-
Published:2024-03-28
Issue:7
Volume:29
Page:1521
-
ISSN:1420-3049
-
Container-title:Molecules
-
language:en
-
Short-container-title:Molecules
Author:
Fang Yangyang1, Xiang Wei1, Cui Jinwei1, Jiao Bining2, Su Xuesu1
Affiliation:
1. College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China 2. Key Laboratory of Quality and Safety Control for Citrus Fruits, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing 400712, China
Abstract
Inflammation is an essential contributor to various human diseases. Diosmetin (3′,5,7-trihydroxy-4′-methoxyflavone), a citrus flavonoid, can be used as an anti-inflammatory agent. All the information in this article was collected from various research papers from online scientific databases such as PubMed and Web of Science. These studies have demonstrated that diosmetin can slow down the progression of inflammation by inhibiting the production of inflammatory mediators through modulating related pathways, predominantly the nuclear factor-κB (NF-κB) signaling pathway. In this review, we discuss the anti-inflammatory properties of diosmetin in cellular and animal models of various inflammatory diseases for the first time. We have identified some deficiencies in current research and offer suggestions for further advancement. In conclusion, accumulating evidence so far suggests a very important role for diosmetin in the treatment of various inflammatory disorders and suggests it is a candidate worthy of in-depth investigation.
Reference127 articles.
1. Sanches, V.L., de Souza Mesquita, L.M., Viganó, J., Contieri, L.S., Pizani, R., Chaves, J., da Silva, L.C., de Souza, M.C., Breitkreitz, M.C., and Rostagno, M.A. (2022). Insights on the Extraction and Analysis of Phenolic Compounds from Citrus Fruits: Green Perspectives and Current Status. Crit. Rev. Anal. Chem., 1–27. 2. Saini, R.K., Ranjit, A., Sharma, K., Prasad, P., Shang, X., Gowda, K.G.M., and Keum, Y.-S. (2022). Bioactive Compounds of Citrus Fruits: A Review of Composition and Health Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes. Antioxidants, 11. 3. Flavonoids in Tropical Citrus Species;Roowi;J. Agric. Food. Chem.,2011 4. Flavone-di--glycosides in juices from Southern Italy;Caristi;Food Chem.,2006 5. Yan, Y., Liu, X., Gao, J., Wu, Y., and Li, Y. (2020). Inhibition of TGF-β Signaling in Gliomas by the Flavonoid Diosmetin Isolated from Dracocephalum peregrinum L.. Molecules, 25.
|
|