Facile Access to 2-Selenoxo-1,2,3,4-tetrahydro-4-quinazolinone Scaffolds and Corresponding Diselenides via Cyclization between Methyl Anthranilate and Isoselenocyanates: Synthesis and Structural Features-Reference-Cited by-同舟云学术

Facile Access to 2-Selenoxo-1,2,3,4-tetrahydro-4-quinazolinone Scaffolds and Corresponding Diselenides via Cyclization between Methyl Anthranilate and Isoselenocyanates: Synthesis and Structural Features

Published:2022-09-07 Issue:18 Volume:27 Page:5799
ISSN:1420-3049
Container-title:Molecules
language:en
Short-container-title:Molecules

Author:

Osmanov Vladimir K.,Chipinsky Evgeniy V.,Khrustalev Victor N.^ORCID,Novikov Alexander S.^ORCID,Askerov Rizvan Kamiloglu^ORCID,Chizhov Alexander O.,Borisova Galina N.^ORCID,Borisov Alexander V.^ORCID,Grishina Maria M.,Kurasova Margarita N.,Kirichuk Anatoly A.,Peregudov Alexander S.,Kritchenkov Andreii S.^ORCID,Tskhovrebov Alexander G.^ORCID

Abstract

A practical method for the synthesis of 2-selenoxo-1,2,3,4-tetrahydro-4-quinazolinone was reported. The latter compounds were found to undergo facile oxidation with H2O2 into corresponding diselenides. Novel organoselenium derivatives were characterized by the 1H, 77Se, and 13C NMR spectroscopies, high-resolution electrospray ionization mass spectrometry, IR, elemental analyses (C, H, N), and X-ray diffraction analysis for several of them. Novel heterocycles exhibited multiple remarkable chalcogen bonding (ChB) interactions in the solid state, which were studied theoretically.

Funder

Russian Science Foundation

RUDN University Strategic Academic Leadership Program

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

Link

https://www.mdpi.com/1420-3049/27/18/5799/pdf

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