[18F]fluoride Activation and 18F-Labelling in Hydrous Conditions—Towards a Microfluidic Synthesis of PET Radiopharmaceuticals
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Published:2023-12-26
Issue:1
Volume:29
Page:147
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ISSN:1420-3049
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Container-title:Molecules
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language:en
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Short-container-title:Molecules
Author:
Ovdiichuk Olga1, Lahdenpohja Salla2ORCID, Béen Quentin1, Tanguy Laurent3, Kuhnast Bertrand2, Collet-Defossez Charlotte14ORCID
Affiliation:
1. Nancyclotep, Molecular Imaging Platform, 54500 Vandoeuvre-les-Nancy, France 2. Université Paris Saclay, CEA Inserm, CNRS, BioMaps, 91401 Orsay, France 3. PMB-Alcen, 13790 Peynier, France 4. Université de Lorraine, Inserm, IADI, 54000 Nancy, France
Abstract
18F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical step in the preparation of 18F-labelled tracers is the anhydrous F-18 nucleophilic substitution reaction, which involves [18F]F− anions generated in aqueous media by the cyclotron. For this, azeotropic drying by distillation is widely used in standard synthesisers, but microfluidic systems are often not compatible with such a process. To avoid this step, several methods compatible with aqueous media have been developed. We summarised the existing approaches and two of them have been studied in detail. [18F]fluoride elution efficiencies have been investigated under different conditions showing high 18F-recovery. Finally, a large scope of precursors has been assessed for radiochemical conversion, and these hydrous labelling techniques have shown their potential for tracer production using a microfluidic approach, more particularly compatible with iMiDEV™ cassette volumes.
Funder
Great East European Regional Development Fund Great East Regional Council France Relaunch Plan BPI France France Life Imaging Network
Subject
Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science
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