An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Author:

Aksenov Dmitrii A.1,Akulova Alesia S.1,Aleksandrova Elena A.1,Aksenov Nicolai A.1ORCID,Leontiev Alexander V.1ORCID,Aksenov Alexander V.1

Affiliation:

1. Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., 355009 Stavropol, Russia

Abstract

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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