Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions

Author:

Fan Liangxin1ORCID,Zhu Xinxin1,Liu Xingyuan1,He Fangyu1,Yang Guoyu1,Xu Cuilian1,Yang Xifa2

Affiliation:

1. Department of Chemical Biology, School of Sciences, Henan Agricultural University, Zhengzhou 450002, China

2. Institute of Pesticide, School of Plant Protection, Henan Agricultural University, Zhengzhou 450002, China

Abstract

3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.

Publisher

MDPI AG

Subject

Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science

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