Cannabidiol-Loaded Nanocarriers and Their Therapeutic Applications

Author:

Assadpour Elham12,Rezaei Atefe3ORCID,Das Sabya Sachi45ORCID,Krishna Rao Balaga Venkata4ORCID,Singh Sandeep Kumar4,Kharazmi Mohammad Saeed6,Jha Niraj Kumar78ORCID,Jha Saurabh Kumar7910,Prieto Miguel A.11ORCID,Jafari Seid Mahdi111213ORCID

Affiliation:

1. Food Industry Research Co., Gorgan 49138-15739, Iran

2. Food and Bio-Nanotech International Research Center (Fabiano), Gorgan University of Agricultural Sciences and Natural Resources, Gorgan 49138-15739, Iran

3. Department of Food Science and Technology, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran

4. Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India

5. School of Pharmaceutical and Population Health Informatics, DIT University, Dehradun 248009, India

6. Faculty of Medicine, University of California, Riverside, CA 92679, USA

7. Department of Biotechnology, School of Engineering and Technology (SET), Sharda University, Greater Noida 201310, India

8. School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India

9. Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India

10. Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal University, Dehradun 248007, India

11. Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, E-32004 Ourense, Spain

12. Department of Food Materials and Process Design Engineering, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan 49189-43464, Iran

13. College of Food Science and Technology, Hebei Agricultural University, Baoding 071001, China

Abstract

Cannabidiol (CBD), one of the most promising constituents isolated from Cannabis sativa, exhibits diverse pharmacological actions. However, the applications of CBD are restricted mainly due to its poor oral bioavailability. Therefore, researchers are focusing on the development of novel strategies for the effective delivery of CBD with improved oral bioavailability. In this context, researchers have designed nanocarriers to overcome limitations associated with CBD. The CBD-loaded nanocarriers assist in improving the therapeutic efficacy, targetability, and controlled biodistribution of CBD with negligible toxicity for treating various disease conditions. In this review, we have summarized and discussed various molecular targets, targeting mechanisms and types of nanocarrier-based delivery systems associated with CBD for the effective management of various disease conditions. This strategic information will help researchers in the establishment of novel nanotechnology interventions for targeting CBD.

Publisher

MDPI AG

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

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