Affiliation:
1. Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150, Zabolotnogo Str., 03143 Kyiv, Ukraine
Abstract
The connection between chronic psychological stress and the onset of various diseases, including diabetes, HIV, cancer, and cardiovascular conditions, is well documented. This review synthesizes current research on the neurological, immune, hormonal, and genetic pathways through which stress influences disease progression, affecting multiple body systems: nervous, immune, cardiovascular, respiratory, reproductive, musculoskeletal, and integumentary. Central to this review is an evaluation of 16 Behavioral Stress Reduction Programs (BSRPs) across over 200 studies, assessing their effectiveness in mitigating stress-related health outcomes. While our findings suggest that BSRPs have the potential to enhance the effectiveness of medical therapies and reverse disease progression, the variability in study designs, sample sizes, and methodologies raises questions about the generalizability and robustness of these results. Future research should focus on long-term, large-scale studies with rigorous methodologies to validate the effectiveness of BSRPs.
Reference350 articles.
1. Inflammatory Theory of Depression;Talarowska;Psychiatr. Polska,2018
2. Quintana, M., and Rivera, O. (2012). Mindfulness Training Online for Stress Reduction, A Global Measure. Annual Review of Cybertherapy and Telemedicine 2012, IOS Press.
3. Gene-Stress-Epigenetic Regulation of FKBP5: Clinical and Translational Implications;Zannas;Neuropsychopharmacology,2016
4. Domínguez-Gerpe, L., and Rey-Méndez, M. (2001). Alterations Induced by Chronic Stress in Lymphocyte Subsets of Blood and Primary and Secondary Immune Organs of Mice. BMC Immunol., 2.
5. Stress Reduction Correlates with Structural Changes in the Amygdala;Carmody;Soc. Cogn. Affect. Neurosci.,2010