Mollaret’s Meningitis due to Herpes Simplex Virus 2: A Case Report and Review of the Literature

Author:

Gabrielli Liliana1ORCID,Banchini Isabella2,Petrisli Evangelia1ORCID,Piccirilli Giulia1ORCID,Venturoli Simona1,Pavoni Matteo2,Cantiani Alessia2,Lanna Federica2,Campoli Caterina3ORCID,Montironi Matteo3,Giannella Maddalena34,Lazzarotto Tiziana12ORCID

Affiliation:

1. Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy

2. Department of Medical and Surgical Sciences, Section of Microbiology, University of Bologna, 40138 Bologna, Italy

3. Infectious Diseases Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy

4. Department of Medical and Surgical Sciences, Infectious Diseases Section, Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy

Abstract

Mollaret’s meningitis is a rare neurological disorder characterized by recurrent episodes of aseptic lymphocytic meningitis, often associated with herpes simplex virus 2 (HSV-2) infection. We report the case of a 39 y.o. Italian woman who experienced four episodes of aseptic lymphocytic meningitis between 2004 and 2023, diagnosed as Mollaret’s meningitis. In each episode, the patient presented with fever, severe headache and photophobia. In two episodes cutaneous vesicles in the left gluteal area preceding meningitis symptoms were also reported. A diagnostic evaluation included a physical–chemical analysis and a real-time PCR of the cerebrospinal fluid (CSF). The CSF presented pleocytosis with lymphocytic predominance and a positive HSV-2 load, with a peak of 1234 copies/mL. The patient was treated successfully with acyclovir, and the symptoms resolved without neurological sequelae. This case highlights the importance of comprehensive diagnostic testing and vigilant monitoring to manage Mollaret’s syndrome effectively.

Funder

NextGenerationEU-MUR PNRR

Publisher

MDPI AG

Reference32 articles.

1. La meningite endothelio-leucocytaire multirecurrent benigne. Syndrome nouveau ou maladie nouvelle. Documents clinique;Mollaret;Rev. Neurol.,1944

2. Isolation of herpes simplex virus type I in recurrent (Mollaret) meningitis;Steel;Ann. Neurol.,1982

3. Comparative neurovirulence of herpes simplex virus type 1 strains after peripheral or intracerebral inoculation of BALB/c mice;Dix;Infect. Immun.,1983

4. Herpes Simplex Virus Type 1 DNA in Cerebrospinal Fluid of a Patient with Mollaret’s Meningitis;Yamamoto;N. Engl. J. Med.,1991

5. Mollaret Cells Detected in a Patient with Varicella-Zoster Virus Meningitis;Ohmichi;Clin. Neurol. Neurosurg.,2012

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3