Learning from the Invaders: What Viruses Teach Us about RNA-Based Regulation in Microbes

Author:

Sarin L. PeterORCID

Abstract

Viruses feature an evolutionary shaped minimal genome that is obligately dependent on the cellular transcription and translation machinery for propagation. To suppress host cell immune responses and ensure efficient replication, viruses employ numerous tactics to favor viral gene expression and protein synthesis. This necessitates a carefully balanced network of virus- and host-encoded components, of which the RNA-based regulatory mechanisms have emerged as particularly interesting albeit insufficiently studied, especially in unicellular organisms such as archaea, bacteria, and yeasts. Here, recent advances that further our understanding of RNA-based translation regulation, mainly through post-transcriptional chemical modification of ribonucleosides, codon usage, and (virus-encoded) transfer RNAs, will be discussed in the context of viral infection.

Funder

Novo Nordisk Foundation

Sigrid Jusélius Foundation

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

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