Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species-Reference-Cited by-同舟云学术

Re-Evaluation of the Cross-Reactions of the Antibody against the Causative Agent for Paracoccidioidomycosis Ceti; Paracoccidioides ceti and the Related Fungal Species

Published:2023-09-28 Issue:10 Volume:11 Page:2428
ISSN:2076-2607
Container-title:Microorganisms
language:en
Short-container-title:Microorganisms

Author:

Kanegae Hikaru¹,de Souza Suguiura Igor Massahiro²³^ORCID,Tashiro Rentaro⁴,Konno Toshihiro¹⁴⁵,Hou De-Xing¹⁶,Sano Ayako¹⁴⁵^ORCID,Eto Takeshi⁵,Ueda Keiichi⁷,Hossain Md. Amzad¹⁴⁵

Affiliation:

1. The United Graduate School of Agricultural Sciences, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan

2. Department of Pathological Sciences, State University of Londrina, P.O. Box 10011, Londrina 86057-970, PR, Brazil

3. Paraná State Secretariat of Health, Department of Health Surveillance, 17th Health Region, Alameda Miguel Blasi, 76-Centro, Londrina 86010-070, PR, Brazil

4. Graduate School of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagami-Gun 903-0213, Japan

5. Faculty of Agriculture, University of the Ryukyus, Sembaru 1, Nishihara-Cho, Nakagami-Gun 903-0213, Japan

6. Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan

7. Okinawa Churashima Foundation, Aza Ishikawa 888, Motobu-Cho, Kunigami-Gun 905-0206, Japan

Abstract

Paracoccidioidomycosis ceti (PCM-C) is a chronic granulomatous keloidal dermatitis in cetaceans that has been reported worldwide and is caused by Paracoccidioides ceti. Serological cross-reactions among highly pathogenic fungal infections and related diseases have been reported. However, the true cross-reaction of antibodies against P. ceti has remained unknown due to the use of positive control sera from infected dolphins. This study aimed to re-evaluate antibodies from mechanically dislodged fungal cells in the infected tissue of a PCM-C case and demonstrate the actual cross-reaction. The results revealed a limited cross-reaction between PCM-C and paracoccidioidomycosis, while the antibodies did not react with other pathogens such as Coccidioides posadasii, Histoplasama capsulatum, and Arthrographis kalrae. Thus, the method for evaluation of the antibody against PCM-C is reliable, and there is potential for epidemiological study.

Funder

University of the Ryukyus Foundation

United Graduate School of Agricultural Sciences, Kagoshima University

Publisher

MDPI AG

Subject

Virology,Microbiology (medical),Microbiology

Link

https://www.mdpi.com/2076-2607/11/10/2428/pdf

Reference16 articles.

1. Seyedmousavi, S., de Hoog, G.S., Guillot, J., and Verweij, P.E. (2018). Emerging and Epizootic Fungal Infections in Animals, Springer.

2. Risk of zoonotic transmission from dolphins to humans;Reif;Vector Borne Zoonotic Dis.,2013

3. Vilela, R., de Hoog, S., Bensch, K., Bagagli, E., and Mendoza, L. (2023). A taxonomic review of the genus Paracoccidioides, with focus on the uncultivable species. PLoS Negl. Trop. Dis., 17.

4. Kanegae, H., Suguiura, M.I., Sasaki, K., Otsuka, M., Hamano, T., Tashiro, R., Ono, M.A., Wada, S., Itano, E.N., and Hossain, M.A. (2023). Latent cases of Paracoccidioidomycosis ceti in an Atlantic bottlenose dolphin (Tursiops truncatus) and a false killer whale (Pseudorca crassidens) diagnosed by the combination of polymerase chain reaction and loop-mediated isothermal amplification. JJZWMed, in press.

5. Immunohistochemical cross-reactivity between Paracoccidioides spp. from dolphins and Histoplasma capsulatum;Shumoto;Mycopathologia,2018