Affiliation:
1. Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los Alimentos, Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Calle Santiago Ramón y Cajal 20, 45115 Alfara del Patriarca, Valencia, Spain
Abstract
Salmonella spp. has been globally recognized as one of the leading causes of acute human bacterial gastroenteritis resulting from the consumption of animal-derived products. Salmonella Enteritidis, S. Typhimurium, and its monophasic variant are the main serovars responsible for human disease. However, a serovar known as S. Infantis has emerged as the fourth most prevalent serovar associated with human disease. A total of 95% of isolated S. Infantis serovars originate from broilers and their derived products. This serovar is strongly associated with an elevated antimicrobial (AMR) and multidrug resistance, a resistance to disinfectants, an increased tolerance to environmental mercury, a heightened virulence, and an enhanced ability to form biofilms and attach to host cells. Furthermore, this serovar harbors genes that confer resistance to colistin, a last-resort antibiotic in human medicine, and it has the potential to acquire additional transferable AMR against other critically important antimicrobials, posing a new and significant challenge to global public health. This review provides an overview of the current status of the S. Infantis serovar in the poultry sector, focusing on its key virulence factors, including its virulence genes, antimicrobial resistance, and biofilm formation. Additionally, novel holistic strategies for controlling S. Infantis along the entire food chain are presented in this review.
Subject
Virology,Microbiology (medical),Microbiology
Reference135 articles.
1. GBD (Globar Burden of Diseases) (2023, January 05). Diarrhoeal Disease Trends in the GBD 2015 Study: Optimism Tempered by Scepticism. Available online: www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(17)30336-5.pdf.
2. Graziani, C., Losasso, C., Luzzi, I., Ricci, A., Scavia, G., and Pasquali, P. (2017). Foodborne Diseases, Elsevier Inc.. [3rd ed.].
3. Salmonella spp. in poultry: A constant challenge and new insights;Velhner;J. Hell. Vet. Med. Soc.,2018
4. Lapierre, L., Cornejo, J., Zavala, S., Galarce, N., Sánchez, F., Benavides, M.B., Guzmán, M., and Sáenz, L. (2020). Phenotypic and genotypic characterization of virulence factors and susceptibility to antibiotics in Salmonella infantis strains isolated from chicken meat: First findings in Chile. Animals, 10.
5. WHO (World Health Organization) (2021, February 02). Salmonella (Non-Typhoidal). Available online: https://www.who.int/news-room/fact-sheets/detail/Salmonella-(non-typhoidal).
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献