Affiliation:
1. Faculty of Chemistry, Lomonosov Moscow State University, Lenin Hills 1/3, Moscow 119991, Russia
Abstract
Today, the production and use of various samples of recombinant protein/polypeptide toxins is known and is actively developing. This review presents state-of-the-art in research and development of such toxins and their mechanisms of action and useful properties that have allowed them to be implemented into practice to treat various medical conditions (including oncology and chronic inflammation applications) and diseases, as well as to identify novel compounds and to detoxify them by diverse approaches (including enzyme antidotes). Special attention is given to the problems and possibilities of the toxicity control of the obtained recombinant proteins. The recombinant prions are discussed in the frame of their possible detoxification by enzymes. The review discusses the feasibility of obtaining recombinant variants of toxins in the form of protein molecules modified with fluorescent proteins, affine sequences and genetic mutations, allowing us to investigate the mechanisms of toxins’ bindings to their natural receptors.
Funder
State Task of Lomonosov Moscow State University
Subject
Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis
Reference131 articles.
1. The role of vaccines in combatting antimicrobial resistance;Micoli;Nat. Rev. Microbiol.,2021
2. Shilova, O., Shramova, E., Proshkina, G., and Deyev, S. (2021). Natural and designed toxins for precise therapy: Modern approaches in experimental oncology. Int. J. Mol. Sci., 22.
3. Streptococcal bacterial components in cancer therapy;Marzhoseyni;Cancer Gene Ther.,2022
4. Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens;Khatuntseva;Int. J. Biol. Macromol.,2022
5. Antibodies and venom peptides: New modalities for ion channels;Wulff;Nat. Rev. Drug. Discov.,2019
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献