Effectiveness and Safety of SARS-CoV-2 Vaccination in HIV-Infected Patients—Real-World Study

Author:

Bociąga-Jasik Monika12,Lara Martyna2,Raczyńska Aleksandra2,Wizner Barbara3ORCID,Polański Stanisław4,Mlicka-Kowalczyk Ewa4,Garlicki Aleksander12,Sanak Marek4ORCID

Affiliation:

1. Department of Infectious and Tropical Diseases, Jagiellonian University Medical College, 30-688 Krakow, Poland

2. Department of Infectious Diseases, University Hospital, 30-688 Krakow, Poland

3. Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 30-688 Kraków, Poland

4. Division of Molecular Biology and Clinical Genetics, Department of Medicine, Jagiellonian University Medical College, 31-066 Kraków, Poland

Abstract

The development of COVID-19 vaccines has been a triumph of biomedical research. However, there are still challenges, including assessment of their immunogenicity in high-risk populations, including PLWH. In the present study, we enrolled 121 PLWH aged >18 years, that were vaccinated against COVID-19 in the Polish National Vaccination Program. Patients filled in questionnaires regarding the side effects of vaccination. Epidemiological, clinical, and laboratory data were collected. The efficacy of COVID-19 vaccines was evaluated with an ELISA that detects IgG antibodies using a recombinant S1 viral protein antigen. The interferon-gamma release assay (IGRA) was applied to quantitate interferon-gamma (IFN-γ) to assess cellular immunity to SARS-CoV-2. In total, 87 patients (71.9%) received mRNA vaccines (BNT162b2-76 (59.5%), mRNA-1273- 11 (9.1%)). A total of 34 patients (28.09%) were vaccinated with vector-based vaccines (ChAdOx Vaxzevria- 20 (16.52%), Ad26.COV2.S- 14 (11.6%)). A total of 95 (78.5%) of all vaccinated patients developed a protective level of IgG antibodies. Only eight PLWH (6.6%) did not develop cellular immune response. There were six patients (4.95%) that did not develop a cellular and humoral response. Analysis of variance proved that the best humoral and cellular response related to the administration of the mRNA-1273 vaccine. COVID-19 vaccines were found to be immunogenic and safe in PLWH. Vaccination with mRNA vaccines were related to better humoral and cellular responses.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Drug Discovery,Pharmacology,Immunology

Reference29 articles.

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