A Highly Selective Electrochemical Sensor Based on Molecularly Imprinted Copolymer Functionalized with Arginine for the Detection of Chloramphenicol in Honey

Author:

Lai Tingrun1,Shu Hui1,Yao Bo1,Lai Siying1,Chen Ting2,Xiao Xuechun1,Wang Yude3ORCID

Affiliation:

1. National Center for International Research on Photoelectric and Energy Materials, School of Materials and Energy, Yunnan University, Kunming 650504, China

2. Institute of Materials Science and Devices, School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou 215009, China

3. Yunnan Key Laboratory of Carbon Neutrality and Green Low-Carbon Technologies, Yunnan University, Kunming 650504, China

Abstract

Developing an efficient method for chloramphenicol (CAP) detection is of great significance for food safety. Arginine (Arg) was selected as a functional monomer. Benefiting from its excellent electrochemical performance, which is different from traditional functional monomers, it can be combined with CAP to form a highly selective molecularly imprinted polymer (MIP) material. It overcomes the shortcoming of poor MIP sensitivity faced by traditional functional monomers, and achieves high sensitivity detection without compounding other nanomaterials, greatly reducing the preparation difficulty and cost investment of the sensor. The possible binding sites between CAP and Arg molecules were calculated by molecular electrostatic potential (MEP). A low-cost, non-modified MIP electrochemical sensor was developed for the high-performance detection of CAP. The prepared sensor has a wide linear range from 1 × 10−12 mol L−1 to 5 × 10−4 mol L−1, achieves a very low concentration CAP detection, and the detection limit is 1.36 × 10−13 mol L−1. It also exhibits excellent selectivity, anti-interference, repeatability, and reproducibility. The detection of CAP in actual honey samples was achieved, which has important practical value in food safety.

Funder

National Natural Science Foundation of China

Yunnan University’s Research Innovation Fund for Graduate Students

Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province

Publisher

MDPI AG

Subject

Clinical Biochemistry,General Medicine,Analytical Chemistry,Biotechnology,Instrumentation,Biomedical Engineering,Engineering (miscellaneous)

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