Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles-Reference-Cited by-同舟云学术

Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles

Published:2024-08-19 Issue:8 Volume:16 Page:1086
ISSN:1999-4923
Container-title:Pharmaceutics
language:en
Short-container-title:Pharmaceutics

Author:

Karnopp Juliana Camila Fischer¹,Jorge Juliana¹^ORCID,da Silva Jaqueline Rodrigues²,Boldo Diego¹,Del Pino Santos Kristiane Fanti¹,Duarte Adriana Pereira¹,de Castro Gustavo Rocha³^ORCID,de Azevedo Ricardo Bentes²^ORCID,Prada Ariadna Lafourcade⁴,Amado Jesús Rafael Rodríguez⁵^ORCID,Martines Marco Antonio Utrera¹^ORCID

Affiliation:

1. Postgraduate Program in Chemistry, Chemistry Institute, Federal University of Mato Grosso do Sul, Campo Grande 79079-900, MS, Brazil

2. Postgraduate Program in Nanoscience and Nanotechnology, Biological Science Institute, University of Brasilia, Brasilia 70910-900, DF, Brazil

3. Postgraduate Program in Environmental Biotechnology, Bioscience Institute, Sao Paulo State University, Botucatu 18618-000, SP, Brazil

4. Postgraduate Program in Biotechnology, Faculty of Pharmacy, Food and Nutrition, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil

5. Postgraduate Program in Health Sciences, Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79804-970, MS, Brazil

Abstract

This study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy. The nanoparticles were designed with a diameter between 20 and 50 nm to optimize cellular uptake and avoid rapid clearance from the bloodstream. The synthesis method involved modifying a previously reported technique to reduce particle size. Successful functionalization with CLB was confirmed through various techniques, including Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The cytotoxicity of the CLB-functionalized nanoparticles (MSN@NH2-CLB) was evaluated against human lung adenocarcinoma cells (A549) and colon carcinoma cells (CT26WT). The results suggest significantly higher cytotoxicity of MSN@NH2-CLB compared to unbound CLB, with improved selectivity towards cancer cells over normal cells. This suggests that MSN@NH2-CLB holds promise as a drug delivery system for targeted cancer therapy.

Funder

Universidade Federal de Mato Grosso do Sul

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico—Brasil

Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul—Brasil

Publisher

MDPI AG

Link

https://www.mdpi.com/1999-4923/16/8/1086/pdf

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