Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions
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Published:2024-09-13
Issue:9
Volume:16
Page:1202
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ISSN:1999-4923
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Container-title:Pharmaceutics
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language:en
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Short-container-title:Pharmaceutics
Author:
Harwansh Ranjit K.1ORCID, Deshmukh Rohitas1ORCID, Shukla Vijay Pratap1, Khunt Dignesh2ORCID, Prajapati Bhupendra Gopalbhai34ORCID, Rashid Summya5, Ali Nemat6ORCID, Elossaily Gehan M.7, Suryawanshi Vijendra Kumar8ORCID, Kumar Arun9ORCID
Affiliation:
1. Institute of Pharmaceutical Research, GLA University, Mathura 281406, India 2. School of Pharmacy, Gujarat Technological University, Gandhinagar 382027, India 3. Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, India 4. Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand 5. Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia 6. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia 7. Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 11597, Saudi Arabia 8. Faculty of Pharmacy, Bharti Vishwavidyalaya, Durg 491001, India 9. School of Pharmacy, Sharda University, Greater Noida 201310, India
Abstract
Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, and strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it has been associated with low permeability and bioavailability issues, limiting their efficacy. GA belongs to BCS (Biopharmaceutics classification system) class III (high solubility and low probability). In this context, novel drug delivery approaches played a vital role in resolving these GA issues. Nanocarrier systems help improve drug moiety’s physical and chemical stability by encapsulating them into a lipidic or polymeric matrix or core system. In this regard, researchers have developed a wide range of nanocarrier systems for GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanoparticles, nanostructured lipid carriers, polymer conjugates, etc. In the present review, different search engines like Scopus, PubMed, ScienceDirect, and Google Scholar have been referred to for acquiring recent information on the theme of the work. Therefore, this review paper aims to emphasize several novel drug delivery systems, patents, and clinical updates of GA.
Funder
Prince Sattam bin Abdulaziz University
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