An Update on Recent Advances of Photodynamic Therapy for Primary Cutaneous Lymphomas

Author:

Liu Wei-Ting1,Wang Han-Tang1,Yeh Yi-Hsuan2,Wong Tak-Wah134ORCID

Affiliation:

1. Department of Dermatology, Cancer Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan

2. School of Medicine, National Cheng Kung University, Tainan 701, Taiwan

3. Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan

4. Center of Applied Nanomedicine, National Cheng Kung University, Tainan 701, Taiwan

Abstract

Primary cutaneous lymphomas are rare non-Hodgkin lymphomas consisting of heterogeneous disease entities. Photodynamic therapy (PDT) utilizing photosensitizers irradiated with a specific wavelength of light in the presence of oxygen exerts promising anti-tumor effects on non-melanoma skin cancer, yet its application in primary cutaneous lymphomas remains less recognized. Despite many in vitro data showing PDT could effectively kill lymphoma cells, clinical evidence of PDT against primary cutaneous lymphomas is limited. Recently, a phase 3 “FLASH” randomized clinical trial demonstrated the efficacy of topical hypericin PDT for early-stage cutaneous T-cell lymphoma. An update on recent advances of photodynamic therapy in primary cutaneous lymphomas is provided.

Funder

National Cheng Kung University Hospital

National Cheng Kung University

Ministry of Education (MOE) in Taiwan

Publisher

MDPI AG

Subject

Pharmaceutical Science

Reference75 articles.

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2. Dobos, G., Pohrt, A., Ram-Wolff, C., Lebbé, C., Bouaziz, J.D., Battistella, M., Bagot, M., and de Masson, A. (2020). Epidemiology of Cutaneous T-Cell Lymphomas: A Systematic Review and Meta-Analysis of 16,953 Patients. Cancers, 12.

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