Mesoporous Silica Nanoparticles as a Gene Delivery Platform for Cancer Therapy

Author:

Khaliq Nisar Ul1ORCID,Lee Juyeon1,Kim Joohyeon1,Kim Yejin1,Yu Sohyeon23,Kim Jisu23,Kim Sangwoo23,Sung Daekyung2ORCID,Kim Hyungjun1ORCID

Affiliation:

1. Department of Chemistry and Bioscience, Kumoh National Institute of Technology, 61 Daehak-ro, Gumi 39177, Republic of Korea

2. Center for Bio-Healthcare Materials, Bio-Convergence Materials R&D Division, Korea Institute of Ceramic Engineering and Technology, 202 Osongsaengmyeong 1-ro, Osong-eup, Heungdeok-gu, Cheongju 28160, Republic of Korea

3. Department of Chemical and Biomolecular Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea

Abstract

Cancer remains a major global health challenge. Traditional chemotherapy often results in side effects and drug resistance, necessitating the development of alternative treatment strategies such as gene therapy. Mesoporous silica nanoparticles (MSNs) offer many advantages as a gene delivery carrier, including high loading capacity, controlled drug release, and easy surface functionalization. MSNs are biodegradable and biocompatible, making them promising candidates for drug delivery applications. Recent studies demonstrating the use of MSNs for the delivery of therapeutic nucleic acids to cancer cells have been reviewed, along with their potential as a tool for cancer therapy. The major challenges and future interventions of MSNs as gene delivery carriers for cancer therapy are discussed.

Funder

Kumoh National Institute of Technology

Publisher

MDPI AG

Subject

Pharmaceutical Science

Reference111 articles.

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