Enhancing Wound Healing: A Novel Topical Emulsion Combining CW49 Peptide and Lavender Essential Oil for Accelerated Regeneration and Antibacterial Protection

Author:

Jaramillo Valentina1ORCID,Díaz Erika1ORCID,Muñoz Laura N.2,González-Barrios Andrés Fernando2ORCID,Rodríguez-Cortina Jader3ORCID,Cruz Juan C.1ORCID,Muñoz-Camargo Carolina1ORCID

Affiliation:

1. Department of Biomedical Engineering, Universidad de los Andes, Bogotá 111711, Colombia

2. Department of Chemical and Food Engineering, Universidad de los Andes, Bogotá 111711, Colombia

3. Corporación Colombiana de Investigación Agropecuaria—AGROSAVIA, Centro de Investigación Tibaitatá, Mosquera 250047, Colombia

Abstract

Wound healing is a complex process involving blood cells, extracellular matrix, and parenchymal cells. Research on biomimetics in amphibian skin has identified the CW49 peptide from Odorrana grahami, which has been demonstrated to promote wound regeneration. Additionally, lavender essential oil exhibits anti-inflammatory and antibacterial activities. Given these considerations, we propose an innovative emulsion that combines the CW49 peptide with lavender oil. This novel formulation could serve as a potent topical treatment, potentially fostering the regeneration of damaged tissues and providing robust antibacterial protection for skin wounds. This study investigates the physicochemical properties, biocompatibility, and in vitro regenerative capacity of the active components and the emulsion. The results show that the emulsion possesses appropriate rheological characteristics for topical application. Both the CW49 peptide and lavender oil exhibit high viability in human keratinocytes, indicating their biocompatibility. The emulsion induces hemolysis and platelet aggregation, an expected behavior for such topical treatments. Furthermore, the lavender-oil emulsion demonstrates antibacterial activity against both Gram-positive and Gram-negative bacterial strains. Finally, the regenerative potential of the emulsion and its active components is confirmed in a 2D wound model using human keratinocytes. In conclusion, the formulated emulsion, which combines the CW49 peptide and lavender oil, shows great promise as a topical treatment for wound healing. Further research is needed to validate these findings in more advanced in vitro models and in vivo settings, potentially leading to improved wound-care management and novel therapeutic options for patients with skin injuries.

Funder

Department of Biomedical Engineering

Vice Presidency for Research and Creation’s Publication Fund at Universidad de los Andes

Publisher

MDPI AG

Subject

Pharmaceutical Science

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