Metabolomics as a Promising Resource Identifying Potential Biomarkers for Inflammatory Bowel Disease

Author:

Bauset Cristina,Gisbert-Ferrándiz LauraORCID,Cosín-Roger Jesús

Abstract

Inflammatory bowel disease (IBD) is a relapsing chronic disorder of the gastrointestinal tract characterized by disruption of epithelial barrier function and excessive immune response to gut microbiota. The lack of biomarkers providing early diagnosis or defining the status of the pathology difficulties an accurate assessment of the disease. Given the different metabolomic profiles observed in IBD patients, metabolomics may reveal prime candidates to be studied, which may help in understanding the pathology and identifying novel therapeutic targets. In this review, we summarize the most current advances describing the promising metabolites such as lipids or amino acids found through untargeted metabolomics from serum, faecal, urine and biopsy samples.

Funder

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana

Conselleria d'Educació, Investigació, Cultura i Esport

Publisher

MDPI AG

Subject

General Medicine

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