Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study-Reference-Cited by-同舟云学术

Home-Based Transcranial Direct Current Stimulation in Primary Progressive Aphasia: A Pilot Study

Published:2024-04-17 Issue:4 Volume:14 Page:391
ISSN:2076-3425
Container-title:Brain Sciences
language:en
Short-container-title:Brain Sciences

Author:

Neophytou Kyriaki¹^ORCID,Williamson Kelly¹,Herrmann Olivia¹,Afthinos Alexandros¹²^ORCID,Gallegos Jessica¹^ORCID,Martin Nadine³,Tippett Donna C.¹⁴⁵^ORCID,Tsapkini Kyrana¹⁶

Affiliation:

1. Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Phipps 488, Baltimore, MD 21287, USA

2. Cooper Medical School of Rowan University, Rowan University, 401 Broadway, Camden, NJ 08103, USA

3. Department of Communication Sciences and Disorders, Temple University, 1701 N. 13th Street, Philadelphia, PA 19122, USA

4. Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Phipps 174, Baltimore, MD 21287, USA

5. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 N. Caroline Street, Baltimore, MD 21287, USA

6. Department of Cognitive Science, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA

Abstract

Background: This study aims to determine (a) if home-based anodal transcranial direct current stimulation (a-tDCS) delivered to the left supramarginal gyrus (SMG) coupled with verbal short-term memory/working memory (vSTM/WM) treatment (“RAM”, short for “Repeat After Me”) is more effective than sham-tDCS in improving vSTM/WM in patients with primary progressive aphasia (PPA), and (b) whether tDCS effects generalize to other language and cognitive abilities. Methods: Seven PPA participants received home-based a-tDCS and sham-tDCS coupled with RAM treatment in separate conditions in a double-blind design. The treatment task required participants to repeat word spans comprising semantically and phonologically unrelated words in the same and reverse order. The evaluation of treatment effects was carried out using the same tasks as in the treatment but with different items (near-transfer effects) and tasks that were not directly related to the treatment (far-transfer effects). Results: A-tDCS showed (a) a significant effect in improving vSTM abilities, measured by word span backward, and (b) a generalization of this effect to other language abilities, namely, spelling (both real words and pseudowords) and learning (retention and delayed recall). Conclusions: These preliminary results indicate that vSTM/WM intervention can improve performance in trained vSTM/WM tasks in patients with PPA, especially when augmented with home-based tDCS over the left SMG.

Funder

National Institutes of Health

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-3425/14/4/391/pdf

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