Affiliation:
1. Department of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
Abstract
Dopamine is an important neurotransmitter that plays a biological role by binding to dopamine receptors. The dopaminergic system regulates neural activities, such as reward and punishment, memory, motor control, emotion, and sleep–wake. Numerous studies have confirmed that the dopaminergic system has the function of maintaining wakefulness in the body. In recent years, there has been increasing evidence that the sleep–wake cycle in the brain has similar neurobrain network mechanisms to those associated with the loss and recovery of consciousness induced by general anesthesia. With the continuous development and innovation of neurobiological techniques, the dopaminergic system has now been proved to be involved in the emergence from general anesthesia through the modulation of neuronal activity. This article is an overview of the dopaminergic system and the research progress into its role in wakefulness and general anesthesia recovery. It provides a theoretical basis for interpreting the mechanisms regulating consciousness during general anesthesia.
Reference96 articles.
1. General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis;Brown;Annu. Rev. Neurosci.,2011
2. How Do General Anaesthetics Work?;Antkowiak;Naturwissenschaften,2001
3. General Anaesthesia: From Molecular Targets to Neuronal Pathways of Sleep and Arousal;Franks;Nat. Rev. Neurosci.,2008
4. Zhang, K., Pan, J., and Yu, Y. (2022). Regulation of Neural Circuitry under General Anesthesia: New Methods and Findings. Biomolecules, 12.
5. The Neural Circuits Underlying General Anesthesia and Sleep;Moody;Anesth. Analg.,2021
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献