Behavior of Rats in a Self-Paced Risky Decision-Making Task Based on Definite Probability

Abstract

Risky decision-making (RDM) is when individuals make choices based on the definite cognition for the probabilities of the options. Risk is embodied in the certainty of reward, and the smaller the probability is, the greater the risk will be. As simulated in human behavior paradigms, RDM scenarios in real life are often guided by external cues that inform the likelihood of receiving certain rewards. There are few studies on the neural basis of RDM behavior guided by external cues, which is related to the relative paucity of the animal behavioral paradigms. Here, we established a cue-guided RDM task to detect the behavior of rats making a decision between a small certain reward and a large uncertain reward in a naturalistic manner. The reward of the risk option could be adjusted to observe the change of choice. Our results showed that: (1) rats were able to master the operation of the cue-guided RDM task; (2) many rats were inclined to choose risk rather than the safe option when the reward expectations were equal; (3) rats were able to adjust the decision strategy in time upon a change in risk, suggesting that they have the ability to perceive risk indicated by the external cues.