Changes in Plasma TPH2, GDNF, Trk-b, BDNF, and proBDNF in People Who Died by Suicide

Author:

Liu Xiaoyu1,Li Shangda1ORCID,Yu Yueran2,Hu Jianbo1345,Xu Yi1345

Affiliation:

1. Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China

2. Department of Infectious Diseases, Tongde Hospital of Zhejiang Province, Hangzhou 310003, China

3. The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou 310003, China

4. Brain Research Institute of Zijingang Campus of Zhejiang University, Hangzhou 310003, China

5. Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou 310003, China

Abstract

Recent studies have shown that neuropeptides and neurotrophic factors may be involved in the pathophysiological mechanisms of suicide. However, the current research on this aspect is still insufficient. Our study aimed to explore the biological patterns of suicide deaths, including levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2. The researchers selected 25 normal control patients matched by age with 30 suicide deaths. We used enzyme-linked immunosorbent assays to detect the levels of BDNF, proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 in the plasma of suicide and control subjects. proBDNF, BDNF/proBDNF, Trk-b, GDNF, and TPH2 levels are shown as the median (25th–75th percentile). BDNF levels are shown as the mean (standard error of the mean). (1) The levels of plasma TPH2 and proBDNF in people who died by suicide were significantly higher than those in the control group. (2) The plasma levels of GDNF and BDNF/proBDNF in the suicide group were obviously lower than those in the control group. (3) There was no significant difference in plasma BDNF or Trk-b concentrations between the suicide group and the control group.Plasma TPH2, GDNF, and proBDNF levels are related to suicide. Plasma neurotrophic factor markers may predict suicide risk.

Funder

Key Research Project of Zhejiang Province

Publisher

MDPI AG

Subject

General Neuroscience

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