Potential Regulation of miRNA-29 and miRNA-9 by Estrogens in Neurodegenerative Disorders: An Insightful Perspective

Author:

Ebada Mahmoud A.123ORCID,Mostafa Abdalrhman4ORCID,Gadallah Al-Hussein A.5,Alkanj Souad3,Alghamdi Badrah S.67,Ashraf Ghulam Md78ORCID,Abuzenadah Adel M.910,Alserihi Raed F.91112ORCID,Wadaa-Allah Ahmed13ORCID,Salama Mohamed14

Affiliation:

1. Neurologist, Nasr City Hospital for Health Insurance, Cairo 11765, Egypt

2. Resident, Egyptian Fellowship of Neurology, Ministry of Health and Population of Egypt, Cairo 4262124, Egypt

3. Faculty of Medicine, Zagazig University, Zagazig 44519, Egypt

4. Intern Physician, Mansoura University Hospitals, Dakahlia 7650030, Egypt

5. Resident at the Egyptian Fellowship Program of Clinical Pathology, Assuit 71515, Egypt

6. Neuroscience Unit, Department of Physiology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia

7. Pre-Clinical Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

8. Department of Medical Laboratory Sciences, College of Health Sciences, Sharjah Institute for Medical Research, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates

9. Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia

10. King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21859, Saudi Arabia

11. Hematology Research Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia

12. Nanomedicine Unit, Center of Innovation in Personalized Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia

13. Biochemistry Department, Faculty of Science, Ain Shams University, Cairo 4392001, Egypt

14. Institute of Global Health and Human Ecology, the American University in Cairo, Cairo 4728120, Egypt

Abstract

Finding a link between a hormone and microRNAs (miRNAs) is of great importance since it enables the adjustment of genetic composition or cellular functions without needing gene-level interventions. The dicer-mediated cleavage of precursor miRNAs is an interface link between miRNA and its regulators; any disruption in this process can affect neurogenesis. Besides, the hormonal regulation of miRNAs can occur at the molecular and cellular levels, both directly, through binding to the promoter elements of miRNAs, and indirectly, via regulation of the signaling effects of the post-transcriptional processing proteins. Estrogenic hormones have many roles in regulating miRNAs in the brain. This review discusses miRNAs, their detailed biogenesis, activities, and both the general and estrogen-dependent regulations. Additionally, we highlight the relationship between miR-29, miR-9, and estrogens in the nervous system. Such a relationship could be a possible etiological route for developing various neurodegenerative disorders.

Funder

Institutional Fund Projects

Publisher

MDPI AG

Subject

General Neuroscience

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3