Mathematical Modelling of Tuberculosis Outbreak in an East African Country Incorporating Vaccination and Treatment

Abstract

In this paper, we develop a deterministic mathematical epidemic model for tuberculosis outbreaks in order to study the disease’s impact in a given population. We develop a qualitative analysis of the model by showing that the solution of the model is positive and bounded. The global stability analysis of the model uses Lyapunov functions and the threshold quantity of the model, which is the basic reproduction number is estimated. The existence and uniqueness analysis for Caputo fractional tuberculosis outbreak model is presented by transforming the deterministic model to a Caputo sense model. The deterministic model is used to predict real data from Uganda and Rwanda to see how well our model captured the dynamics of the disease in the countries considered. Furthermore, the sensitivity analysis of the parameters according to R0 was considered in this study. The normalised forward sensitivity index is used to determine the most sensitive variables that are important for infection control. We simulate the Caputo fractional tuberculosis outbreak model using the Adams–Bashforth–Moulton approach to investigate the impact of treatment and vaccine rates, as well as the disease trajectory. Overall, our findings imply that increasing vaccination and especially treatment availability for infected people can reduce the prevalence and burden of tuberculosis on the human population.