Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid-Reference-Cited by-同舟云学术

Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid

Published:2023-07-26 Issue:15 Volume:15 Page:3317
ISSN:2072-6643
Container-title:Nutrients
language:en
Short-container-title:Nutrients

Author:

Beyer María Paz¹^ORCID,Videla Luis A.²^ORCID,Farías Camila¹^ORCID,Valenzuela Rodrigo¹^ORCID

Affiliation:

1. Department of Nutrition, Faculty of Medicine, University of Chile, Santiago 8380000, Chile

2. Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago 7810000, Chile

Abstract

Docosahexaenoic acid (C22:6n-3, DHA) is the precursor of specialized pro-resolving lipid mediators (SPMs), such as resolvin, protectin, and maresin families which have been considered therapeutic bioactive compounds for human health. Growing evidence indicates that DHA and SPMs are beneficial strategies in the amelioration, regulation, and duration of inflammatory processes through different biological actions. The present review discusses the reported therapeutic benefits of SPMs on various diseases and their potential clinical applications.

Funder

Fondo Nacional de Desarrollo Científico y Tecnológico

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Link

https://www.mdpi.com/2072-6643/15/15/3317/pdf

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3. Ferreira, I., Falcato, F., Bandarra, N., and Rauter, A.P. (2022). Resolvins, protectins, and maresins: DHA-derived specialized pro-resolving mediators, biosynthetic pathways, synthetic approaches, and their role in inflammation. Molecules, 27.