Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review
Author:
Valenti Maria Teresa1ORCID, Zerlotin Roberta2, Cominacini Mattia3ORCID, Bolognin Silvia4, Grano Maria2ORCID, Dalle Carbonare Luca3ORCID
Affiliation:
1. Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37100 Verona, Italy 2. Department of Precision and Regenerative Medicine and Ionian Area, University of Bari, 70124 Bari, Italy 3. Department of Engineering for the Innovation Medicine, University of Verona, 37100 Verona, Italy 4. MERLN Institute, Maastricht University, Universiteitssingel 40, 6229 ET Maastricht, The Netherlands
Abstract
Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression with diverse roles in various biological processes. In recent years, research into circRNAs’ involvement in bone biology has gained significant attention, unveiling their potential as novel regulators and biomarkers in bone-related disorders and diseases. CircRNAs, characterized by their closed-loop structure, exhibit stability and resistance to degradation, underscoring their functional significance. In bone tissue, circRNAs are involved in critical processes such as osteogenic differentiation, osteoclastogenesis, and bone remodeling through intricate molecular mechanisms including microRNA regulation. Dysregulated circRNAs are associated with various bone disorders, suggesting their potential as diagnostic and prognostic biomarkers. The therapeutic targeting of these circRNAs holds promise for addressing bone-related conditions, offering new perspectives for precision medicine. Thus, circRNAs constitute integral components of bone regulatory networks, impacting both physiological bone homeostasis and pathological conditions. This review provides a comprehensive overview of circRNAs in bone biology, emphasizing their regulatory mechanisms, functional implications, and therapeutic potential.
Reference120 articles.
1. Bombieri, C., Corsi, A., Trabetti, E., Ruggiero, A., Marchetto, G., Vattemi, G., Valenti, M.T., Zipeto, D., and Romanelli, M.G. (2024). Advanced Cellular Models for Rare Disease Study: Exploring Neural, Muscle and Skeletal Organoids. Int. J. Mol. Sci., 25. 2. Valenti, M.T., Dalle Carbonare, L., and Mottes, M. (2016). Osteogenic differentiation in healthy and pathological conditions. Int. J. Mol. Sci., 18. 3. Li, D., Yang, C., Tian, Y., Chen, Z., Qian, A., and Yin, C. (2021). Roles and Mechanism of Long Noncoding RNAs in Bone Diseases. Noncoding RNAs Bone, Springer. 4. Haque, S., and Harries, L.W. (2017). Circular RNAs (circRNAs) in health and disease. Genes, 8. 5. Kirgiafini, D., Kyrgiafini, M.-A., Gournaris, T., and Mamuris, Z. (2024). Understanding Circular RNAs in Health, Welfare, and Productive Traits of Cattle, Goats, and Sheep. Animals, 14.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|