Abstract
Voltage-gated channels play an essential role in action potential propagation when their closed gates open, but their role when they are closed needs to be investigated. So, in this study, a quantum mechanical approach using the idea of quantum tunneling was used to calculate the conductance of closed channels for different ions. It was found that the conductance due to quantum tunneling of ions through the closed channels does not affect the resting membrane potential. However, under different circumstances, including change in the mass or the charge of the ion and the residues of the hydrophobic gate, the model of quantum tunneling would be useful to understand and explain several actions, processes, and phenomena in the biological systems.
Subject
Physics and Astronomy (miscellaneous),Astronomy and Astrophysics,Atomic and Molecular Physics, and Optics,Statistical and Nonlinear Physics
Reference23 articles.
1. Guyton and Hall Textbook of Medical Physiology E-Book;Hall,2015
2. Hydrophobic Gating in Ion Channels
3. A Theoretical Study to Explain the Referred Pain Phenomenon and Its Characteristics via Quantum Tunneling of Potassium Ions Through the Channels of Neuronal Membrane;Qaswal;NeuroQuantology,2019
4. A quantitative description of membrane current and its application to conduction and excitation in nerve
5. Modern Physics;Serway,2005
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献