Viral Nucleases

Author:

Wang Zhengqiang1ORCID,Geraghty Robert J.1ORCID

Affiliation:

1. Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA

Abstract

Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]

Funder

National Institute of Allergy and Infectious Diseases

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

Reference14 articles.

1. Nucleases: Diversity of structure, function and mechanism;Yang;Q. Rev. Biophys.,2011

2. Ribonuclease H, an unexploited target for antiviral intervention against HIV and hepatitis B virus;Tramontano;Antivir. Res.,2019

3. The Cap-Snatching Mechanism of Bunyaviruses;Olschewski;Trends Microbiol.,2020

4. Cap-Snatching Leads to Novel Viral Proteins;Russell;Cell,2020

5. Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage;Wang;J. Virol.,2017

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