Three-Dimensional Printed Patient-Specific Vestibular Augmentation: A Case Report

Author:

Johansson Linh12345ORCID,Latorre Jose Luis6,Liversain Margaux5,Thorel Emilie5ORCID,Raymond Yago5,Ginebra Maria-Pau12378ORCID

Affiliation:

1. Biomaterials, Biomechanics and Tissue Engineering Group (BBT), Department of Materials Science and Engineering, Universitat Politècnica de Catalunya BarcelonaTech (UPC), Av. Eduard Maristany, 16, 08019 Barcelona, Spain

2. Barcelona Research Centre in Multiscale Science and Engineering, Escola d’Enginyeria de Barcelona Est (EEBE), Universitat Politècnica de Catalunya (UPC), Av. Eduard Maristany, 10-14, 08019 Barcelona, Spain

3. Biomedical Engineering Research Center (CREB), Universitat Politècnica de Catalunya (UPC), Av. Diagonal, 647, 08028 Barcelona, Spain

4. Institut de Recerca Sant Joan de Déu (IRSJD), 39-57, 08950 Esplugues del Llobregat, Spain

5. Mimetis Biomaterials S.L., Carrer de Cartagena, 245, 3E, 08025 Barcelona, Spain

6. Freelance Implantologist: Oris Dental Center, C. de Joan Güell, 108, 08028 Barcelona, Spain

7. Institute for Bioengineering of Catalonia (IBEC), BIST, Carrer Baldiri Reixac 10-12, 08028 Barcelona, Spain

8. CIBER de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029 Madrid, Spain

Abstract

Background: The anterior maxilla is challenging regarding aesthetic rehabilitation. Current bone augmentation techniques are complex and 3D-printed bioceramic bone grafts can simplify the intervention. Aim: A four-teeth defect in the anterior maxilla was reconstructed with a 3D-printed synthetic patient-specific bone graft in a staged approach for dental implant delivery. Methods: The bone graft was designed using Cone-Beam Computed Tomography (CBCT) images. The bone graft was immobilized with fixation screws. Bone augmentation was measured on CBCT images at 11 days and 8 and 13 months post-surgery. A biopsy sample was retrieved at reentry (10 months post-augmentation) and evaluated by histological and micro-computed tomography assessments. The definitive prosthesis was delivered 5 months post-reentry and the patient attended a visit 1-year post-loading. Results: A total bone width of 8 mm was achieved (3.7 mm horizontal bone gain). The reconstructed bone remained stable during the healing period and was sufficient for placing two dental implants (with an insertion torque > 35 N·cm). The fractions of new bone, bone graft, and soft tissue in the biopsy were 40.77%, 41.51%, and 17.72%, respectively. The histological assessment showed no signs of encapsulation, and mature bone was found in close contact with the graft, indicating adequate biocompatibility and suggesting osteoconductive properties of the graft. At 1-year post-loading, the soft tissues were healthy, and the dental implants were stable. Conclusions: The anterior maxilla’s horizontal ridge can be reconstructed using a synthetic patient-specific 3D-printed bone graft in a staged approach for implant placement. The dental implants were stable and successful 1-year post-loading.

Funder

Spanish Government

Generalitat of Catalunya

Mimetis Biomaterials S.L.

European Commission

Publisher

MDPI AG

Reference28 articles.

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