Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination

Abstract

A new voltammetry method for the highly sensitive antibacterial drug ciprofloxacin (CIP) is presented using glassy carbon electrodes modified with hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The use of a modified glassy carbon electrode in the form of hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo) led to an LOD value as low as 6.0 µmol L−1 with a measurement sensitivity of 3.33 µA µmol L−1. The described procedure was successfully applied for CIP determination in samples with complex matrices, such as urine or plasma, and also in pharmaceutical products and antibiotic discs with satisfactory recovery values ranging between 94–104%. The proposed electrode was characterised by great stability, with the possibility of use for about 4 weeks without any significant change in the CIP peak current. The repeatability of the CIP response on the eCNF/CNT/NiCo/GC is also very good; its value measured and expressed as RSD is equal to 2.4% for a CIP concentration of 0.025 µmol L−1 (for 7 consecutive CIP voltammogram registrations). The procedure for electrode preparation is quick and simple and does not involve the use of expensive apparatus.