Affiliation:
1. Hubei Key Laboratory of Drug Synthesis and Optimization, Jingchu University of Technology, Jingmen 448000, China
Abstract
1-Iodoalkynes are one type of the most reactive and the most practical intermediates in organic synthesis. Here, some facile and efficient methods for the 1-iodination of terminal alkynes are developed using N-iodosuccinimide (NIS) as an iodination reagent and some inexpensive mild bases as catalysts. K2CO3 and 4-dimethylaminopyridine (DMAP) have been proven to be the most suitable inorganic and organic bases, succeeding in 17 examples with excellent yields (up to 99%).
Funder
Projects of Hubei Education Department
Jingmen Science and Technology Projects
Research Programs of Jingchu University of Technology
Innovation and Entrepreneurship Training Program for College Students