Long Non-Coding RNAs as “MYC Facilitators”-Reference-Cited by-同舟云学术

Long Non-Coding RNAs as “MYC Facilitators”

Published:2023-09-01 Issue:3 Volume:30 Page:389-399
ISSN:1873-149X
Container-title:Pathophysiology
language:en
Short-container-title:Pathophysiology

Author:

García-Caballero Daniel¹^ORCID,Hart Jonathan R.¹,Vogt Peter K.¹^ORCID

Affiliation:

1. Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Abstract

In this article, we discuss a class of MYC-interacting lncRNAs (long non-coding RNAs) that share the following criteria: They are direct transcriptional targets of MYC. Their expression is coordinated with the expression of MYC. They are required for sustained MYC-driven cell proliferation, and they are not essential for cell survival. We refer to these lncRNAs as “MYC facilitators” and discuss two representative members of this class of lncRNAs, SNHG17 (small nuclear RNA host gene) and LNROP (long non-coding regulator of POU2F2). We also present a general hypothesis on the role of lncRNAs in MYC-mediated transcriptional regulation.

Funder

National Cancer Institute

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/1873-149X/30/3/30/pdf

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