The Effect of Low-Temperature Microwave Plasma on Wound Regeneration in Diabetic Rats
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Published:2023-12-10
Issue:12
Volume:11
Page:3399
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ISSN:2227-9717
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Container-title:Processes
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language:en
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Short-container-title:Processes
Author:
Bogdanov Todor12ORCID, Marinova Plamena23, Traikov Lubomir1, Gateva Pavlina1, Sedloev Theophil14, Petrov Andrey1, Vodenicharov Vlayko1, Georgiev Rosen1, Bakalov Dimitar1ORCID, Sabit Zafer1, Tafradjiiska-Hadjiolova Radka1, Hikov Todor1
Affiliation:
1. Faculty of Medicine, Medical University—Sofia, “St. Georgi Sofiyski” St. No. 1, 1431 Sofia, Bulgaria 2. Clean & CircleCoC, Sofia University, 15 Tzar Osvoboditel Blvd., 1504 Sofia, Bulgaria 3. Faculty of Forest Industry, University of Forestry, 10 Kliment Ohridski Blvd., 1797 Sofia, Bulgaria 4. Department of Surgery, University Hospital Queen Joanna—ISUL, ul. “Byalo more” No. 8, 1527 Sofia, Bulgaria
Abstract
Impaired wound healing in diabetic individuals presents a significant clinical challenge, and this study explores the impact of low-temperature microwave plasma in an argon atmosphere, a type of cold atmospheric plasma (CAP), on wound regeneration in diabetic rats. The findings reveal that this CAP treatment accelerates wound regeneration in diabetic rats, promoting faster wound closure, reducing inflammation, and enhancing critical regenerative processes such as angiogenesis, collagen synthesis, and extracellular matrix remodeling. Additionally, CAP exhibits anti-inflammatory effects by modulating the immune response towards a pro-regenerative state. These results underscore the potential of CAP in diabetic wound care, offering a promising approach to address delayed wound healing in diabetic patients and potentially improving the quality of life for those with chronic diabetic wounds.
Funder
Science and Education for Smart Growth Operational Program EU through the ESIF
Subject
Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering
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