Magnetic Calcium Phosphate Cement for Hyperthermia Treatment of Bone Tumors

Abstract

This article reports, for the first time, the ‘proof-of-concept’ results on magnetic monetite (CaHPO4)-based calcium phosphate cements (CPCs) compositions developed for the hyperthermia treatment of bone tumors. Hyperthermia involves the heating of a tumor within a temperature range of 40–45 °C, inducing apoptosis in the tumor cells. This process holds promising potential in the field of cancer treatment and has been proven to be more effective than conventional therapeutics. Hence, we aimed to develop cement compositions that are capable of the hyperthermia treatment of bone tumors. To achieve that central goal, we incorporated iron oxide (Fe3O4), a ferromagnetic material, into monetite and hypothesized that, upon the application of a magnetic field, magnetite will generate heat and ablate the tumor cells near the implantation site. The results confirmed that an optimized content of magnetite incorporation in monetite can generate heat in the range of 40–45 °C upon the application of a magnetic field. Furthermore, the compositions were bioactive and cytocompatible with an osteoblastic cell line.