Abstract
Concerns about the safety of anesthetic agents in children arose after animal studies revealed disruptions in neurodevelopment after exposure to commonly used anesthetic drugs. These animal studies revealed that volatile inhalational agents, propofol, ketamine, and thiopental may have detrimental effects on neurodevelopment and cognitive function, but dexmedetomidine and xenon have been shown to have neuroprotective properties. The neurocognitive effects of benzodiazepines have not been extensively studied, so their effects on neurodevelopment are undetermined. However, experimental animal models may not truly represent the pathophysiological processes in children. Multiple landmark studies, including the MASK, PANDA, and GAS studies have provided reassurance that brief exposure to anesthesia is not associated with adverse neurocognitive outcomes in infants and children, regardless of the type of anesthetic agent used.
Subject
Pediatrics, Perinatology and Child Health
Reference64 articles.
1. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits;J. Neurosci.,2003
2. Cognitive and behavioral outcomes after early exposure to anesthesia and surgery;Pediatrics,2011
3. Update on developmental anesthesia neurotoxicity;Curr. Opin. Anaesthesiol.,2017
4. Review of preclinical studies on pediatric general anesthesia-induced developmental neurotoxicity;Neurotoxicol. Teratol.,2017
5. (2022, September 10). FDA Drug Safety Communication: FDA Review Results in New Warnings about Using General Anesthetics and Sedation Drugs in Young Children and Pregnant Women, Available online: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-review-results-new-warnings-about-using-general-anesthetics-and.
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献