Juvenile Idiopathic Arthritis Associated Uveitis

Author:

Carlsson Emil,Beresford Michael W.,Ramanan Athimalaipet V.,Dick Andrew D.,Hedrich Christian M.ORCID

Abstract

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease. The development of associated uveitis represents a significant risk for serious complications, including permanent loss of vision. Initiation of early treatment is important for controlling JIA-uveitis, but the disease can appear asymptomatically, making frequent screening procedures necessary for patients at risk. As our understanding of pathogenic drivers is currently incomplete, it is difficult to assess which JIA patients are at risk of developing uveitis. Identification of specific risk factors for JIA-associated uveitis is an important field of research, and in this review, we highlight the genomic, transcriptomic, and proteomic factors identified as potential uveitis risk factors in JIA, and discuss therapeutic strategies.

Funder

Medical Research Council

Versus Arthritis

Great Ormond Street Hospital Charity

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

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