Comparison between Two Different Synthesis Methods of Strontium-Doped Hydroxyapatite Designed for Osteoporotic Bone Restoration

Author:

Codrea Cosmin Iulian12ORCID,Lincu Daniel12ORCID,Atkinson Irina2,Culita Daniela C.2ORCID,Croitoru Alexa-Maria134,Dolete Georgiana134ORCID,Trusca Roxana134,Vasile Bogdan Stefan134ORCID,Stan Miruna Silvia5ORCID,Ficai Denisa134ORCID,Ficai Anton1346ORCID

Affiliation:

1. Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, 060042 Bucharest, Romania

2. Department of Oxide Compounds and Materials Science, Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, 060021 Bucharest, Romania

3. National Research Center for Micro and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania

4. National Centre for Food Safety, National University of Science and Technology Politehnica of Bucharest, Splaiul Independentei 313, 060042 Bucharest, Romania

5. Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, 050095 Bucharest, Romania

6. Academy of Romanian Scientists, Ilfov St. 3, 050044 Bucharest, Romania

Abstract

Development of efficient controlled local release of drugs that prevent systemic side effects is a challenge for anti-osteoporotic treatments. Research for new bone-regeneration materials is of high importance. Strontium (Sr) is known as an anti-resorptive and anabolic agent useful in treating osteoporosis. In this study, we compared two different types of synthesis used for obtaining nano hydroxyapatite (HA) and Sr-containing nano hydroxyapatite (SrHA) for bone tissue engineering. Synthesis of HA and SrHA was performed using co-precipitation and hydrothermal methods. Regardless of the synthesis route for the SrHA, the intended content of Sr was 1, 5, 10, 20, and 30 molar %. The chemical, morphological, and biocompatibility properties of HA and SrHA were investigated. Based on our results, it was shown that HA and SrHA exhibited low cytotoxicity and demonstrated toxic behavior only at higher Sr concentrations.

Funder

National University of Science and Technology Politehnica of Bucharest

Publisher

MDPI AG

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