Affiliation:
1. Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Av. da Universidade Técnica de Lisboa, 1300-477 Lisbon, Portugal
2. Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 1300-477 Lisbon, Portugal
Abstract
Enterococcus spp. are commensals of the gastrointestinal tracts of humans and animals and colonize a variety of niches such as water, soil, and food. Over the last three decades, enterococci have evolved as opportunistic pathogens, being considered ESKAPE pathogens responsible for hospital-associated infections. Enterococci’s ubiquitous nature, excellent adaptative capacity, and ability to acquire virulence and resistance genes make them excellent sentinel proxies for assessing the presence/spread of pathogenic and virulent clones and hazardous determinants across settings of the human–animal–environment triad, allowing for a more comprehensive analysis of the One Health continuum. This review provides an overview of enterococcal fitness and pathogenic traits; the most common clonal complexes identified in clinical, veterinary, food, and environmental sources; as well as the dissemination of pathogenic genomic traits (virulome, resistome, and mobilome) found in high-risk clones worldwide, across the One Health continuum.
Funder
FCT—Fundação para a Ciência e Tecnologia IP Portugal
national funds
Subject
Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology
Reference152 articles.
1. Geraldes, C., Tavares, L., Gil, S., and Oliveira, M. (2022). Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment. Antibiotics, 11.
2. Lebreton, F., Willems, R.J.L., and Gilmore, M.S. (2014). Enterococci: From Commensals to Leading Causes of Drug Resistant Infection, Massachusetts Eye and Ear Infirmary.
3. Antimicrobial-Resistant CC17 Enterococcus faecium: The Past, the Present and the Future;Lee;J. Glob. Antimicrob. Resist.,2019
4. Tracing the Enterococci from Paleozoic Origins to the Hospital;Lebreton;Cell,2017
5. Krawczyk, B., Wityk, P., Gałęcka, M., and Michalik, M. (2021). The Many Faces of Enterococcus spp.—Commensal, Probiotic and Opportunistic Pathogen. Microorganisms, 9.
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献