Genetic Variant of DNAM-1 rs763361 C>T Is Associated with Ankylosing Spondylitis in a Mexican Population

Author:

Vázquez-Reyes Alejandro1,Zambrano-Zaragoza José Francisco1ORCID,Agraz-Cibrián Juan Manuel1,Ayón-Pérez Miriam Fabiola1,Gutiérrez-Silerio Gloria Yareli2ORCID,Del Toro-Arreola Susana3,Alejandre-González Alan Guillermo3,Ortiz-Martínez Liliana4,Haramati Jesse5ORCID,Tovar-Ocampo Iris Celeste1,Victorio-De los Santos Marcelo1,Gutiérrez-Franco Jorge1

Affiliation:

1. Unidad Académica de Ciencias Químico Biológicas y Farmacéuticas (UACQByF), Universidad Autónoma de Nayarit, Tepic 63000, Nayarit, Mexico

2. Laboratorio de Endocrinología y Nutrición, Departamento de Investigación Biomédica, Faculta de Medicina, Universidad Autónoma de Querétaro, Querétaro 76140, Querétaro, Mexico

3. Instituto de Investigación en Enfermedades Crónico Degenerativas, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico

4. Clínica de Reumatología, Servicio de Medicina Interna, Instituto Mexicano del Seguro Social (IMSS), Tepic 63000, Nayarit, Mexico

5. Laboratorio de Inmunobiología, Departamento de Biología Celular y Molecular, Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA), Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico

Abstract

DNAM-1 (CD226) is an activating receptor expressed in CD8+ T cells, NK cells, and monocytes. It has been reported that two SNPs in the DNAM-1 gene, rs763361 C>T and rs727088 G>A, have been associated with different autoimmune diseases; however, the role of DNAM-1 in ankylosing spondylitis has been less studied. For this reason, we focused on the study of these two SNPs in association with ankylosing spondylitis. For this, 34 patients and 70 controls were analyzed using endpoint PCR with allele-specific primers. Our results suggest that rs763361 C>T is involved as a possible protective factor under the CT co-dominant model (OR = 0.34, 95% CI = 0.13–0.88, p = 0.022) and the CT + TT dominant model (OR = 0.39, 95% CI = 0.17–0.90, p = 0.025), while rs727088 G>A did not show an association with the disease in any of the inheritance models. When analyzing the relationships of the haplotypes, we found that the T + A haplotype (OR = 0.31, 95% CI = 0.13–0.73, p = 0.0083) is a protective factor for developing the disease. In conclusion, the CT and CT + TT variants of rs763361 C>T and the T + A haplotype were considered as protective factors for developing ankylosing spondylitis.

Funder

Programa para el Desarrollo Profesional Docente

Patronato of the Universidad Autónoma de Nayarit

Publisher

MDPI AG

Reference28 articles.

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4. Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?;Akassou;Clin. Med. Insights Arthritis Musculoskelet. Disord.,2018

5. Epidemiology of spondyloarthritis in Mexico;Am. J. Med. Sci.,2011

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