LncRNA-Dependent Mechanisms of Transforming Growth Factor-β: From Tissue Fibrosis to Cancer Progression

Author:

Tang Philip Chiu-TsunORCID,Zhang Ying-Ying,Li Jane Siu-Fan,Chan Max Kam-Kwan,Chen JiaoyiORCID,Tang Ying,Zhou Yiming,Zhang Dongmei,Leung Kam-Tong,To Ka-Fai,Tang Sydney Chi-Wai,Lan Hui-YaoORCID,Tang Patrick Ming-KuenORCID

Abstract

Transforming growth factor-β (TGF-β) is a crucial pathogenic mediator of inflammatory diseases. In tissue fibrosis, TGF-β regulates the pathogenic activity of infiltrated immunocytes and promotes extracellular matrix production via de novo myofibroblast generation and kidney cell activation. In cancer, TGF-β promotes cancer invasion and metastasis by enhancing the stemness and epithelial mesenchymal transition of cancer cells. However, TGF-β is highly pleiotropic in both tissue fibrosis and cancers, and thus, direct targeting of TGF-β may also block its protective anti-inflammatory and tumor-suppressive effects, resulting in undesirable outcomes. Increasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in TGF-β-driven tissue fibrosis and cancer progression with a high cell-type and disease specificity, serving as an ideal target for therapeutic development. In this review, the mechanism and translational potential of TGF-β-associated lncRNAs in tissue fibrosis and cancer will be discussed.

Funder

Research Grants Council of Hong Kong

Publisher

MDPI AG

Subject

Genetics,Molecular Biology,Biochemistry

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