Nanoemulsions and Solid Microparticles Containing Pentyl Cinnamate to Control Aedes aegypti

Author:

Almeida Addison12ORCID,Morais Waldenice1,Oliveira Nicolas12,Silva Wilken1,Gomes Ana2,Espindola Laila3,Araujo Marianna4,Araujo Renata5ORCID,Albernaz Lorena3ORCID,De Sousa Damião4ORCID,Aragão Cicero2ORCID,Ferreira Leandro2ORCID

Affiliation:

1. Laboratório de Farmacotécnica, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil

2. Laboratório de Controle de Qualidade de Medicamentos, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil

3. Laboratory of Phamacognosy, Brasília University, Campus Universitário Darcy Ribeiro, Brasília 70910-900, Brazil

4. Laboratory of Pharmaceutical Chemistry, Federal University of Paraíba, João Pessoa 58050-085, Brazil

5. Chemistry Institute, Federal University of Rio Grande do Norte, Natal 59072-970, Brazil

Abstract

The Aedes aegypti mosquito is a vector of severe diseases with high morbidity and mortality rates. The most commonly used industrial larvicides have considerable toxicity for non-target organisms. This study aimed to develop and evaluate liquid and solid carrier systems to use pentyl cinnamate (PC), derived from natural sources, to control Ae. aegypti larvae. The liquid systems consisting of nanoemulsions with different lecithins systems were obtained and evaluated for stability over 30 days. Microparticles (MPs) were obtained by the spray drying of the nanoemulsions using maltodextrin as an adjuvant. Thermal, NMR and FTIR analysis indicated the presence of PC in microparticles. Indeed, the best nanoemulsion system was also the most stable and generated the highest MP yield. The PC larvicidal activity was increased in the PC nanoemulsion system. Therefore, it was possible to develop, characterize and obtain PC carrier systems active against Ae. aegypti larvae.

Funder

Ministério da Saúde

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

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