Potential Neuroprotective Effects of Dietary Omega-3 Fatty Acids on Stress in Alzheimer’s Disease

Author:

Hartnett Kaitlyn B.1,Ferguson Bradley J.234ORCID,Hecht Patrick M.2,Schuster Luke E.5,Shenker Joel I.4,Mehr David R.6,Fritsche Kevin L.7,Belury Martha A.8,Scharre Douglas W.9,Horwitz Adam J.10,Kille Briana M.11,Sutton Briann E.12,Tatum Paul E.13,Greenlief C. Michael14ORCID,Beversdorf David Q.241516ORCID

Affiliation:

1. School of Medicine, University of Missouri-Columbia, Columbia, MO 65212, USA

2. Interdisciplinary Neuroscience Program, University of Missouri-Columbia, Columbia, MO 65212, USA

3. Department of Health Psychology, University of Missouri-Columbia, Columbia, MO 65212, USA

4. Department of Neurology, University of Missouri-Columbia, Columbia, MO 65212, USA

5. School of Medicine, University of Kansas, Kansas City, KS 66160, USA

6. Family & Community Medicine, University of Missouri-Columbia, Columbia, MO 65212, USA

7. Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO 65211, USA

8. Department of Human Sciences, Ohio State University, Columbus, OH 43210, USA

9. Department of Neurology, Ohio State University, Columbus, OH 43210, USA

10. Strock Medical Group, Boulder, CO 80303, USA

11. Children’s Hospital Colorado, Aurora, CO 80045, USA

12. College of Osteopathic Medicine, William Carey University, Hattiesburg, MS 39401, USA

13. Division of Palliative Medicine; Washington University. St. Louis, MO 63110, USA

14. Department of Chemistry, University of Missouri, Columbia, MO 65211, USA

15. Department of Radiology, University of Missouri, Columbia, MO 65212, USA

16. Psychological Sciences, University of Missouri, Columbia, MO 65212, USA

Abstract

Background: A large number of individual potentially modifiable factors are associated with risk for Alzheimer’s disease (AD). However, less is known about the interactions between the individual factors. Methods: In order to begin to examine the relationship between a pair of factors, we performed a pilot study, surveying patients with AD and controls for stress exposure and dietary omega-3 fatty acid intake to explore their relationship for risk of AD. Results: For individuals with the greatest stress exposure, omega-3 fatty acid intake was significantly greater in healthy controls than in AD patients. There was no difference among those with low stress exposure. Conclusions: These initial results begin to suggest that omega-3 fatty acids may mitigate AD risk in the setting of greater stress exposure. This will need to be examined with larger populations and other pairs of risk factors to better understand these important relationships. Examining how individual risk factors interact will ultimately be important for learning how to optimally decrease the risk of AD.

Funder

MU Interdisciplinary Center on Aging

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Reference51 articles.

1. Complementary and alternative medicine approaches in Alzheimer disease and other neurocognitive disorders;Beversdorf;Mo. Med.,2023

2. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission;Livingston;Lancet,2020

3. Promoting Successful Cognitive Aging: A Ten-Year Update;Krivanek;J. Alzheimers Dis.,2021

4. Association of Combined Healthy Lifestyle Factors With Incident Dementia in Patients With Type 2 Diabetes;Wang;Neurology,2022

5. Modifiable, Non-Modifiable, and Clinical Factors Associated with Progression of Alzheimer’s Disease;Loeffler;J. Alzheimers Dis.,2021

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3