Primary, Secondary, and Tertiary Prevention of Congenital Cytomegalovirus Infection

Author:

Sartori Pauline12,Egloff Charles345ORCID,Hcini Najeh67ORCID,Vauloup Fellous Christelle8910,Périllaud-Dubois Claire4511ORCID,Picone Olivier34510,Pomar Léo12ORCID

Affiliation:

1. School of Health Sciences (HESAV), University of Applied Sciences and Arts Western Switzerland, 1011 Lausanne, Switzerland

2. Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland

3. Assistance Publique-Hôpitaux de Paris APHP, Nord, Service de Gynécologie Obstétrique, Hôpital Louis Mourier, 92700 Colombes, France

4. Université de Paris, 75006 Paris, France

5. INSERM, IAME, B.P. 416, 75870 Paris, France

6. Department of Obstetrics and Gynaecology, West French Guiana Hospital Center, French 97320, Guyana

7. CIC Inserm 1424 et DFR Santé Université Guyane, 97320 ST Laurent du Maroni, France

8. Université Paris-Saclay, INSERM U1193, 94804 Villejuif, France

9. Laboratoire de Virologie, AP-HP, Hôpital Paul-Brousse, 94804 Villejuif, France

10. Groupe de Recherche sur les Infections Pendant la Grossesse (GRIG), 75000 Paris, France

11. Virology Laboratory, AP-HP, Sorbonne Université, Hôpital Saint-Antoine, F-75012 Paris, France

Abstract

Cytomegalovirus infection is the most common congenital infection, affecting about 1% of births worldwide. Several primary, secondary, and tertiary prevention strategies are already available during the prenatal period to help mitigate the immediate and long-term consequences of this infection. In this review, we aim to present and assess the efficacy of these strategies, including educating pregnant women and women of childbearing age on their knowledge of hygiene measures, development of vaccines, screening for cytomegalovirus infection during pregnancy (systematic versus targeted), prenatal diagnosis and prognostic assessments, and preventive and curative treatments in utero.

Funder

University of Applied Sciences and Arts Western Switzerland

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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