Author:
Xu Peng,Dong Shuai,Wu Linlin,Bai Yule,Bi Xueqing,Li Yaping,Shu Chang
Abstract
Gestational diabetes mellitus (GDM) is an important metabolic complication of pregnancy, which affects the future health of both the mother and the newborn. The pathogenesis of GDM is not completely clear, but what is clear is that with the development and growth of the placenta, GDM onset and blood glucose is difficult to control, while gestational diabetes patients’ blood glucose drops and reaches normal after placenta delivery. This may be associated with placental secretion of insulin-like growth factor, adipokines, tumor necrosis factor-α, cytokines and insulin resistance. Therefore, endocrine secretion of placenta plays a key role in the pathogenesis of GDM. The influence of DNA methylation of these molecules and pathway-related genes on gene expression is also closely related to the pathogenesis of GDM. Here, this review attempts to clarify the pathogenesis of GDM and the related maternal and placental DNA methylation changes and how they affect metabolic pathways.
Funder
Natural Science Funds in Science and Technology Department of Jilin Province, China
Open Project of Key Laboratory of Organ Regeneration and Transplantation, Ministry of Education
Wu Jieping Medical Foundation
NSFC
Finance Department of Jilin Province, China
Subject
Food Science,Nutrition and Dietetics
Cited by
9 articles.
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