Affiliation:
1. Department of Mechanical Engineering, TOBB University of Economics and Technology, Ankara 06530, Turkey
Abstract
Abdominal aortic aneurysm (AAA) is a critical health disorder, where the abdominal aorta dilates more than 50% of its normal diameter. Enlargement in abdominal aorta alters the hemodynamics and flow-induced forces on the AAA wall. Depending on the flow conditions, the hemodynamic forces on the wall may result in excessive mechanical stresses that lead to AAA rupture. The risk of rupture can be predicted using advanced computational techniques such as computational fluid dynamics (CFD) and fluid–structure interaction (FSI). For a reliable rupture risk assessment, formation of intraluminal thrombus (ILT) and uncertainty in arterial material properties should be taken into account, mainly due to the patient-specific differences and unknowns in AAAs. In this study, AAA models are computationally investigated by performing CFD simulations combined with FSI analysis. Various levels of ILT burdens are artificially generated in a realistic AAA geometry, and the peak effective stresses are evaluated to elucidate the effect of material models and ILT formation. The results indicate that increasing the ILT burden leads to lowered effective stresses on the AAA wall. The material properties of the artery and ILT are also effective on the stresses; however, these effects are limited compared to the effect of ILT volume in the AAA sac.
Subject
Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics
Reference54 articles.
1. Biomechanical Investigation of Disturbed Hemodynamics-Induced Tissue Degeneration in Abdominal Aortic Aneurysms Using Computational and Experimental Techniques;Salman;Front. Bioeng. Biotechnol.,2019
2. New Approaches to Abdominal Aortic Aneurysm Rupture Risk Assessment;McGloughlin;Arterioscler. Thromb. Vasc. Biol.,2010
3. Arzani, A., and Shadden, S.C. (2012, January 20–23). Transport and Mixing in Patient Specific Abdominal Aortic Aneurysms with Lagrangian Coherent Structures. Proceedings of the Summer Bioengineering Conference, Fajardo, Puerto Rico.
4. Characterizations and Correlations of Wall Shear Stress in Aneurysmal Flow;Arzani;J. Biomech. Eng.,2015
5. A longitudinal comparison of hemodynamics and intraluminal thrombus deposition in abdominal aortic aneurysms;Arzani;Am. J. Physiol. Heart Circ. Physiol.,2014
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献