Oxygen Requirement in Overweight/Obese Kidney Transplant Recipients with COVID-19: An Observational Cohort Study
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Published:2023-06-26
Issue:13
Volume:13
Page:2168
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ISSN:2075-4418
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Container-title:Diagnostics
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language:en
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Short-container-title:Diagnostics
Author:
Veronese-Araújo Alexandre1, de Lucena Débora D.12ORCID, Aguiar-Brito Isabella1, Modelli de Andrade Luís Gustavo3, Cristelli Marina P.2, Tedesco-Silva Hélio12, Medina-Pestana José O.12, Rangel Érika B.124ORCID
Affiliation:
1. Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo 04038-031, SP, Brazil 2. Hospital do Rim, São Paulo 04038-002, SP, Brazil 3. Department of Internal Medicine, Botucatu Medical School, University of São Paulo State, Botucatu 18618-687, SP, Brazil 4. Hospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil
Abstract
Introduction: Obesity is one of the components of the cardiometabolic syndrome that contributes to COVID-19 progression and mortality. Immunosuppressed individuals are at greater risk of the COVID-19 burden. Therefore, we sought to investigate the impact of the combination of overweight/obesity and kidney transplant on oxygen (O2) requirements in the COVID-19 setting. Methods: Retrospective analysis of 284 kidney transplant recipients (KTRs) from March/2020 to August/2020 in a single center. We investigated the risk factors associated with O2 requirements in overweight/obese KTRs. Results: Overall, 65.1% had a BMI (body mass index) ≥ 25 kg/m2, 52.4% were male, the mean age was 53.3 ± 11 years old, 78.4% had hypertension, and 41.1% had diabetes mellitus. BMI was an independent risk factor for O2 requirements (OR = 1.07, p = 0.02) alongside age, lymphopenia, and hyponatremia. When overweight/obese KTRs were older, smokers, they presented higher levels of lactate dehydrogenase (LDH), and lower levels of estimated glomerular filtration rate (eGFR), lymphocytes, and sodium at admission, and they needed O2 more often. Conclusion: Being overweight/obese is associated with greater O2 requirements in KTRs, in particular in older people and smokers, with worse kidney allograft functions, more inflammation, and lower sodium levels. Therefore, the early identification of factors that predict a worse outcome in overweight/obese KTRs affected by COVID-19 contributes to risk stratification and therapeutic decisions.
Subject
Clinical Biochemistry
Reference40 articles.
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