CNS Involvement of DLBCL Presenting with an Unusual Non-Enhancing Infiltrative Mass

Author:

Hsueh Fu-Sheng1,Chen Hung-Chieh23ORCID,Tzeng Huey-En45678

Affiliation:

1. Department of Radiology, Taipei Veterans General Hospital, Taipei 11217, Taiwan

2. Department of Radiology, Division of Neuroradiology, Taichung Veterans General Hospital, Taichung 40705, Taiwan

3. School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan

4. Department of Internal Medicine, Division of Hematology and Oncology, Taipei Medical University Hospital, Taipei 110301, Taiwan

5. Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan

6. Department of Medicine, Division of Hematology/Medical Oncology, Taichung Veterans General Hospital, Taichung 40705, Taiwan

7. Ph.D. Program for Cancer Molecular Biology and Drug Discovery, Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110301, Taiwan

8. Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 402202, Taiwan

Abstract

Central nervous system (CNS) involvement in diffuse large B-cell lymphoma (DLBCL) is relatively uncommon, occurring in approximately 5% of cases, with the majority of instances manifesting during relapse and often associated with poor prognoses. The aim of this case report is to present a unique occurrence of non-enhancing relapse of CNS lymphoma. Significantly, the patient had recently encountered a disease involvement in the axilla region, and subsequent to scheduled chemotherapy, she developed persistent neurological symptoms, leading to the discovery of a relapse of the CNS lymphoma. Our focus will be on delineating the clinical presentation, elucidating the findings observed in clinical imaging, and detailing the therapeutic approaches employed in this specific case. By highlighting these aspects, we aim to provide valuable insights into the diagnosis of the atypical presentation of CNS lymphoma.

Publisher

MDPI AG

Subject

Clinical Biochemistry

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